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FGFR1/VEGFR2-IN-3

FGFR1/VEGFR2-IN-3 (Compound 8m) is a dual inhibitor of FGFR1/VEGFR2. FGFR1/VEGFR2-IN-3 exhibits anti-proliferative and anti-migratory activities against cancer cells, and is capable of inducing cell apoptosis[1].

Product Specifications

UNSPSC

12352211

Target

Apoptosis; FGFR; VEGFR

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fgfr1-vegfr2-in-3.html

Smiles

O=C(NN1C(C(C=C(C=CC=C2)C2=C3)=C3C1=O)=O)C4=CC=C5NC(C6=CC=C(OC)C=C6)=NC5=C4

Molecular Formula

C27H18N4O4

Molecular Weight

462.46

References & Citations

[1]Abdel-Mohsen H T, et al. Benzimidazole–dioxoisoindoline conjugates as dual VEGFR-2 and FGFR-1 inhibitors: design, synthesis, biological investigation, molecular docking studies and ADME predictions[J]. RSC advances, 2024, 14 (39) : 28889-28903.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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