FGFR1/VEGFR2-IN-3
FGFR1/VEGFR2-IN-3 (Compound 8m) is a dual inhibitor of FGFR1/VEGFR2. FGFR1/VEGFR2-IN-3 exhibits anti-proliferative and anti-migratory activities against cancer cells, and is capable of inducing cell apoptosis[1].
Product Specifications
UNSPSC
12352211
Target
Apoptosis; FGFR; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr1-vegfr2-in-3.html
Smiles
O=C(NN1C(C(C=C(C=CC=C2)C2=C3)=C3C1=O)=O)C4=CC=C5NC(C6=CC=C(OC)C=C6)=NC5=C4
Molecular Formula
C27H18N4O4
Molecular Weight
462.46
References & Citations
[1]Abdel-Mohsen H T, et al. Benzimidazole–dioxoisoindoline conjugates as dual VEGFR-2 and FGFR-1 inhibitors: design, synthesis, biological investigation, molecular docking studies and ADME predictions[J]. RSC advances, 2024, 14 (39) : 28889-28903.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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