APP/β-Amyloid Recombinant Rabbit Monoclonal Antibody [JE30-54]
Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. It functions as a cell surface receptor and has been implicated as a regulator of synapse formation, neural plasticity, antimicrobial activity, and iron export. It is coded for by the gene APP and regulated by substrate presentation. APP is best known as the precursor molecule whose proteolysis generates amyloid beta (Aβ), a polypeptide containing 37 to 49 amino acid residues, whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
APP, A4, AD1
Swiss Prot
P05067 Human, P12023 Mouse, P08592 Rat
Cellular Locus
Cell membrane, Membrane, Perikaryon, Cell projection, growth cone, clathrin-coated pit, Early endosome, Cytoplasmic vesicle.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within Human Amyloid Precursor Protein aa 671-770 / 770.
Isotype
IgG
Clone
JE30-54
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P, IF-Tissue, IHC-Fr
Positive Control
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:1,000 ;IF-Tissue: 1:200 ;IHC-Fr: 1:500
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 87 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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