Gly-Pro-Glu

Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection [1][2].

Product Specifications

CAS Number

[32302-76-4]

Product Name Alternative

ABBV-075

UNSPSC

12352209

Target

Others

Type

Peptides

Related Pathways

Others

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gly-pro-glu.html

Purity

99.64

Solubility

DMSO : 66.67 mg/mL (ultrasonic; adjust pH to 2 with 1M HCl)

Smiles

O=C(CC[C@H](NC([C@H]1N(CCC1)C(CN)=O)=O)C(O)=O)O

Molecular Formula

C12H19N3O6

Molecular Weight

301.30

References & Citations

[1]Sara VR, et al. Identification of Gly-Pro-Glu (GPE), the aminoterminal tripeptide of insulin-like growth factor 1 which is truncated in brain, as a novel neuroactive peptide. Biochem Biophys Res Commun. 1989 Dec 15;165 (2) :766-71.|[2]Aguado-Llera D, et al. Gly-Pro-Glu protects beta-amyloid-induced somatostatin depletion in the rat cortex. Neuroreport. 2004 Aug 26;15 (12) :1979-82.