Sorbitol dehydrogenase-IN-1

Sorbitol dehydrogenase-IN-1 is a potent and orally active sorbitol dehydrogenase inhibitor with IC50 s of 4, 5 nM for rat and human, respectively. Sorbitol Dehydrogenase (SDH) is an enzyme that belongs to the zinc-containing alcohol dehydrogenase (ADH) family. ADH and ALDH are enzymes that work together to metabolize alcohol[1].

Product Specifications

CAS Number

[300551-49-9]

UNSPSC

12352005

Target

Aldehyde Dehydrogenase (ALDH)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/sorbitol-dehydrogenase-in-1.html

Concentration

10mM

Purity

98.70

Solubility

DMSO : 40 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@@H](C1=NC(N2[C@H](C)CN(C[C@@H]2C)C3=NC(C)=NC(C)=N3)=CC=N1)C

Molecular Formula

C17H25N7O

Molecular Weight

343.43

References & Citations

[1]Mylari BL, et al. A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1- (R) -[4-[4- (4,6-dimethyl[1,3,5]triazin-2-yl) - 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol. J Med Chem. 2002 Sep 26;45 (20) :4398-401.