MDM2-p53-IN-16
MDM2-p53-IN-16 is a MDM2-p53 complex inhibitor with an IC50 value of 4.3 nM to dissociate human p53/MDM2 complex. MDM2-p53-IN-16 reactivates p53, and induces Glioblastoma Multiforme (GBM) cell apoptosis and cell-cycle arrest. MDM2-p53-IN-16 can be used for the cancer research[1].
Product Specifications
CAS Number
[1917350-09-4]
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mdm2-p53-in-16.html
Purity
99.08
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(OC)=O)=O)C(C2=C(C3=CC=CC=C3)NC4=C2C=CC=C4)=O
Molecular Formula
C32H33N3O5
Molecular Weight
539.62
References & Citations
[1]Daniele S, et al. Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM) 2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas. J Med Chem. 2016 May 26;59 (10) :4526-38.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS3803615-01 48 Well
Human Growth-Regulated Protein beta ELISA Kit
Sign In for Pricing
View Details 
MBS3803615-02 96 Well
Human Growth-Regulated Protein beta ELISA Kit
Sign In for Pricing
View Details 
MBS3803615-03 5x 96 Well
Human Growth-Regulated Protein beta ELISA Kit
Sign In for Pricing
View Details MBS3803615-04 10x 96 Well
Human Growth-Regulated Protein beta ELISA Kit
Sign In for Pricing
View Details 
037743-ML405 100 µL
LGALS3, CT (LGALS3, MAC2, Galectin-3, 35kD lectin, Carbohydrate-binding protein 35, Galactose-specific lectin 3, Galactoside-binding protein, IgE-binding protein, L-31, Laminin-binding protein, Lectin L-29, Mac-2 antigen) (MaxLight 405) discontinued
Sign In for Pricing
View Details MBS1431153-01 0.02 mg (E-Coli)
Recombinant Rhodococcus sp. NADH-quinone oxidoreductase subunit I (nuoI)
Sign In for Pricing
View Details