MDM2-p53-IN-16

MDM2-p53-IN-16 is a MDM2-p53 complex inhibitor with an IC50 value of 4.3 nM to dissociate human p53/MDM2 complex. MDM2-p53-IN-16 reactivates p53, and induces Glioblastoma Multiforme (GBM) cell apoptosis and cell-cycle arrest. MDM2-p53-IN-16 can be used for the cancer research[1].

Product Specifications

CAS Number

[1917350-09-4]

UNSPSC

12352005

Target

MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mdm2-p53-in-16.html

Purity

99.08

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(OC)=O)=O)C(C2=C(C3=CC=CC=C3)NC4=C2C=CC=C4)=O

Molecular Formula

C32H33N3O5

Molecular Weight

539.62

References & Citations

[1]Daniele S, et al. Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM) 2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas. J Med Chem. 2016 May 26;59 (10) :4526-38.