Tegobuvir
Tegobuvir is a specific, covalent inhibitor of the HCV NS5B polymerase.
Product Specifications
CAS Number
1000787-75-6
Product Name Alternative
GS 333126; GS-9190
UNSPSC
12352005
Hazard Statement
H302, H315, H320, H335
Target
HCV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Tegobuvir.html
Purity
98.01
Solubility
DMSO : ≥ 50 mg/mL
Smiles
FC1=CC=CC=C1C2=NC3=CN(CC4=NN=C(C5=CC=C(C(F)(F)F)C=C5C(F)(F)F)C=C4)C=CC3=N2
Molecular Formula
C25H14F7N5
Molecular Weight
517.40
Precautions
H302, H315, H320, H335
References & Citations
[1]Bae AS, et al. Allele-specific real-time PCR system for detection of subpopulations of genotype 1a and 1b hepatitis C NS5B Y448H mutant viruses in clinical samples.
 J Clin Microbiol. 2011 Sep;49 (9) :3168-74.|[2]Hebner CM, et al. The HCV non-nucleoside inhibitor Tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function.
 PLoS One. 2012;7 (6) :e39163.|[3]Wong KA, et al. Tegobuvir (GS-9190) potency against HCV chimeric replicons derived from consensus NS5B sequences from genotypes 2b, 3a, 4a, 5a, and 6a.
 Virology. 2012 Jul 20;429 (1) :57-62.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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