AMC-01

AMC-01 is a potent chemical probe that regulates eIF2-α activity. AMC-01 induces protein kinase RNA activation (PKR) kinase and nuclear factor κb (NF-κB) . AMC-01 inhibits apoptosis[1].

Product Specifications

CAS Number

[1047978-71-1]

UNSPSC

12352005

Target

Apoptosis; Eukaryotic Initiation Factor (eIF)

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/amc-01.html

Purity

99.38

Solubility

10 mM in DMSO

Smiles

O=C(O)C(O)=O.COC1=CC=C(Br)C=C1CN2CCN(C(C3=CC=C(C4=CC=CC=C4)C=C3)=O)CC2

Molecular Formula

C27H27BrN2O6

Molecular Weight

555.42

References & Citations

[1]Hong MN, et al. The small molecule '1- (4-biphenylylcarbonyl) -4- (5-bromo-2-methoxybenzyl) piperazine oxalate' and its derivatives regulate global protein synthesis by inactivating eukaryotic translation initiation factor 2-alpha. Cell Stress Chaperones. 2016 May;21 (3) :485-97.