AMC-01
AMC-01 is a potent chemical probe that regulates eIF2-α activity. AMC-01 induces protein kinase RNA activation (PKR) kinase and nuclear factor κb (NF-κB) . AMC-01 inhibits apoptosis[1].
Product Specifications
CAS Number
1047978-71-1
UNSPSC
12352005
Target
Apoptosis; Eukaryotic Initiation Factor (eIF)
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/amc-01.html
Purity
99.38
Solubility
10 mM in DMSO
Smiles
O=C(O)C(O)=O.COC1=CC=C(Br)C=C1CN2CCN(C(C3=CC=C(C4=CC=CC=C4)C=C3)=O)CC2
Molecular Formula
C27H27BrN2O6
Molecular Weight
555.42
References & Citations
[1]Hong MN, et al. The small molecule '1- (4-biphenylylcarbonyl) -4- (5-bromo-2-methoxybenzyl) piperazine oxalate' and its derivatives regulate global protein synthesis by inactivating eukaryotic translation initiation factor 2-alpha. Cell Stress Chaperones. 2016 May;21 (3) :485-97.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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