AMC-01
AMC-01 is a potent chemical probe that regulates eIF2-α activity. AMC-01 induces protein kinase RNA activation (PKR) kinase and nuclear factor κb (NF-κB) . AMC-01 inhibits apoptosis[1].
Product Specifications
CAS Number
1047978-71-1
UNSPSC
12352005
Target
Apoptosis; Eukaryotic Initiation Factor (eIF)
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/amc-01.html
Purity
99.38
Solubility
10 mM in DMSO
Smiles
O=C(O)C(O)=O.COC1=CC=C(Br)C=C1CN2CCN(C(C3=CC=C(C4=CC=CC=C4)C=C3)=O)CC2
Molecular Formula
C27H27BrN2O6
Molecular Weight
555.42
References & Citations
[1]Hong MN, et al. The small molecule '1- (4-biphenylylcarbonyl) -4- (5-bromo-2-methoxybenzyl) piperazine oxalate' and its derivatives regulate global protein synthesis by inactivating eukaryotic translation initiation factor 2-alpha. Cell Stress Chaperones. 2016 May;21 (3) :485-97.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
NSL0751Ca 96 Tests
Canine Platelet-associated immunoglobulins G/M/A (PA-IgG/M/A) ELISA Kit
Sign In for Pricing
View Details 
