Conantokin G

Conantokin G, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G inhibits NMDA-evoked currents in murine cortical neurons with an IC50 of 480 nM. Conantokin G has neuroprotective properties[1][2].

Product Specifications

CAS Number

[93438-65-4]

UNSPSC

12352209

Hazard Statement

H301-H311-H330

Target

IGluR

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/conantokin-g.html

Solubility

10 mM in DMSO

Smiles

NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C(O)=O)C(O)=O)C(N[C@@H](CC(C(O)=O)C(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C(O)=O)C(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C(O)=O)C(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C(O)=O)C(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@H](C(N)=O)CC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C88H138N26O44

Molecular Weight

2264.19

Precautions

P260-P264-P270-P271-P280-P284-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

References & Citations

[1]S D Donevan, et al. Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors. Mol Pharmacol. 2000 Sep;58 (3) :614-23.|[2]A J Williams, et al. Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies. J Pharmacol Exp Ther. 2000 Jul;294 (1) :378-86.