Meloxicam
Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 μM and 36.6 μM for COX-2 and COX-1, respectively.
Product Specifications
CAS Number
[71125-38-7]
UNSPSC
12352005
Hazard Statement
H301, H360, H412
Target
Apoptosis; Autophagy; COX; MMP
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/meloxicam.html
Purity
99.70
Solubility
DMSO : 10 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=C(C1=C(O)C2=CC=CC=C2S(N1C)(=O)=O)NC3=NC=C(C)S3
Molecular Formula
C14H13N3O4S2
Molecular Weight
351.41
Precautions
H301, H360, H412
References & Citations
[1]Lazer ES, et al. Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity. J Med Chem. 1997 Mar 14;40 (6) :980-9.|[2]Iturriaga MP, et al. Meloxicam decreases the migration and invasion of CF41.Mg canine mammary carcinoma cells. Oncol Lett. 2017 Aug;14 (2) :2198-2206.|[3]Fikry EM, et al. Rutin and meloxicam attenuate paw inflammation in mice: Affecting sorbitol dehydrogenase activity. J Biochem Mol Toxicol. 2018 Feb;32 (2) .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX-1; COX-2; MMP-2
Available Sizes
Curated Selection
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