CHR-6494

CHR-6494 is a potent inhibitor of haspin, with an IC50 of 2 nM. CHR-6494 inhibits histone H3T3 phosphorylation. CHR-6494 can be used in the research of cancer[1].

Product Specifications

CAS Number

[1333377-65-3]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Haspin Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CHR-6494.html

Concentration

10mM

Purity

99.28

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CCCNC(C=C1)=NN2C1=NC=C2C3=CC(C=NN4)=C4C=C3

Molecular Formula

C16H16N6

Molecular Weight

292.34

Precautions

H315, H319

References & Citations

[1]Huertas D, et al. Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene. 2012 Mar 15;31 (11) :1408-18.|[2]Han L, et al. Anti-Melanoma Activities of Haspin Inhibitor CHR-6494 Deployed as a Single Agent or in a Synergistic Combination with MEK Inhibitor. J Cancer. 2017 Aug 25;8 (15) :2933-2943.|[3]Chen A, et al. CRISPR/Cas9 screening identifies a kinetochore-microtubule dependent mechanism for Aurora-A inhibitor resistance in breast cancer. Cancer Commun (Lond) . 2021 Feb;41 (2) :121-139.