Hydroquinine
Hydroquinine (Dihydroquinine) is an anti-bacterial agent that inhibits both Gram-positive and Gram-negative bacteria. Hydroquinine inhibits the growth of multidrug-resistant pseudomonas aeruginosa via the suppression of the arginine deiminase pathway genes. Hydroquinine inhibits Plasmodium falciparum and Plasmodium berghei. Hydroquinine displays anti-malarial and demelanizing activities. Hydroquinine effectively induces specific RND-type efflux pump systems in Pseudomonas aeruginosa, particularly the MexCD-OprJ and MexXY efflux pumps. Hydroquinine inhibits Pseudomonas aeruginosa adhesion and biofilm formation. Hydroquinine serves as a precursor for derivatives such as C9 epihydroquinine, 9-acetoxy-10,11-dihydroquinine, and 10,11-dihydroquinine monohydrochloride[1][2][3].
Product Specifications
CAS Number
[522-66-7]
Product Name Alternative
Dihydroquinine
UNSPSC
12352005
Hazard Statement
H315, H317, H319, H334, H335
Target
Bacterial; Parasite; Protein Arginine Deiminase; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Anti-infection; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hydroquinine.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
CC[C@@H]1[C@@H]2C[C@H]([N@](C1)CC2)[C@H](O)C3=CC=NC4=CC=C(OC)C=C43
Molecular Formula
C20H26N2O2
Molecular Weight
326.44
Precautions
H315, H317, H319, H334, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
