Fosfluconazole

Fosfluconazole is a proagent of Fluconazole that is widely used as an antifungal agent.

Product Specifications

CAS Number

[194798-83-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Fosfluconazole.html

Purity

99.16

Solubility

DMSO : 6.2 mg/mL (ultrasonic; warming)

Smiles

FC1=CC=C(C(CN2N=CN=C2)(OP(O)(O)=O)CN3N=CN=C3)C(F)=C1

Molecular Formula

C13H13F2N6O4P

Molecular Weight

386.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Hagiya H, et al. Successful treatment of recurrent candidemia due to candidal thrombophlebitis associated with a central venous catheter using a combination of Fosfluconazole and micafungin. Intern Med. 2013;52 (18) :2139-43.|[2]Yuan H, et al. Evaluation of in vitro models for screening alkaline phosphatase-mediated bioconversion of phosphate ester prodrugs. Drug Metab Dispos. 2009 Jul;37 (7) :1443-7.|[3]Aoyama T, et al. Pharmacokinetics of fluconazole and Fosfluconazole after intraperitoneal administration to peritoneal dialysis rats. Drug Metab Pharmacokinet. 2005 Dec;20 (6) :485-90.