Dehydrocorydaline

Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP[1]. Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities[2]. Dehydrocorydaline shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain[3].

Product Specifications

CAS Number

[30045-16-0]

Product Name Alternative

13-Methylpalmatine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Bcl-2 Family; Caspase; p38 MAPK; Parasite; PARP

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; MAPK/ERK Pathway

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Dehydrocorydaline.html

Purity

99.77

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CC1=C(C=CC(OC)=C2OC)C2=C[N+]3=C1C4=CC(OC)=C(OC)C=C4CC3

Molecular Formula

C22H24NO4+

Molecular Weight

366.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Xu Z, et al. Dehydrocorydaline inhibits breast cancer cells proliferation by inducing apoptosis in MCF-7 cells. Am J Chin Med. 2012;40 (1) :177-85.|[2]Yin ZY, et al. Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines. Sci Rep. 2016 Jun 7;6:27129.|[3]Yoo M, et al. Dehydrocorydaline promotes myogenic differentiation via p38 MAPK activation. Mol Med Rep. 2016 Oct;14 (4) :3029-36.|[4]Nonaka M, et al. Screening of a library of traditional Chinese medicines to identify anti-malarial compounds and extracts. Malar J. 2018 Jun 25;17 (1) :244.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Bax; Bcl-2; Caspase 7; Caspase 8; PARP; Plasmodium

Citation 01

Biochem Pharmacol. 2025 May:235:116820.|Bioengineered. 2022 May;13 (5) :12847-12862.|Ecotoxicol Environ Saf. 2025 Jun 4:300:118460.|Exp Eye Res. 2023 Feb:227:109365.|Front Biosci (Landmark Ed) . 2025 Apr 25;30 (4) :25221.|Front Pharmacol. 2021 May 31:12:653272.|Genomics. 2025 Jun 1:111067.|Int Immunopharmacol. 2024 Jul 23:139:112720.|J Cardiothorac Surg. 2024 Dec 20;19 (1) :665.|J Clin Invest. 2024 Jun 18:e178303.|J Ethnopharmacol. 2024 Aug 31:118738.|J Food Sci. 2025 Apr;90 (4) :e70217.|J Inflamm Res. 2021 Sep 16;14:4669-4686.|New Phytol. 2024 May 13.|Phytomedicine. 2021 Nov:92:153740.|Respir Res. 2025 Apr 12;26 (1) :136.|Tissue Cell. 2023 Dec:85:102218.|Aging (Albany NY) . 2021 May 11;13 (9) :12780-12799.|Aging (Albany NY) . 2021 Oct 7;13 (19) :23133-23148.|Andrology. 2025 Jun 16.|Arthritis Res Ther. 2025 May 31;27 (1) :118.|Biochem Biophys Res Commun. 2018 May 23;499 (4) :743-750. |Biochem Biophys Res Commun. 2018 Sep 5;503 (2) :467-473. |Biochem Pharmacol. 2024 Dec;230 (Pt 1) :116574.|BMC Musculoskelet Disord. 2022 May 30;23 (1) :514.|Bone Joint Res. 2023 Nov 1;12 (11) :677-690.|Comput Math Methods Med. 2021 Aug 2:2021:3337514.|Eur J Histochem. 2025 Jan 21;69 (1) .|Eur J Pharmacol. 2021 Jun 5:900:174069.|FASEB J. 2025 Aug 31;39 (16) :e70945.|Infect Genet Evol. 2022 Jan:97:105158.|J Agric Food Chem. 2023 Oct 25;71 (42) :15538-15552.|J Cell Physiol. 2019 Dec;234 (12) :22463-22476.|J Clin Neurosci. 2020 Aug;78:365-370.|J Mol Histol. 2021 Jun;52 (3) :521-537.|J Nanobiotechnology. 2025 Jul 22;23 (1) :535.|J Nutr. 2020 Jul 1;150 (7) :1731-1737.|Mol Carcinog. 2024 Nov;63 (11) :2190-2204.|Int J Biol Macromol. 2024 May;266 (Pt 1) :130939.|Research Square Preprint. 2020 Dec.