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MBQ-167

MBQ-167 is a dual Rac/Cdc42 inhibitor, with IC50s of 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively.

Product Specifications

CAS Number

2097938-73-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CDK; Ras

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MBQ-167.html

Concentration

10mM

Purity

99.67

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCN1C2=C(C3=C1C=CC=C3)C=C(N4N=NC=C4C5=CC=CC=C5)C=C2

Molecular Formula

C22H18N4

Molecular Weight

338.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Humphries-Bickley T, et al. Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer. Mol Cancer Ther. 2017 May;16 (5) :805-818.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

CDC

Available Sizes

Frequently Asked Questions

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