Vatinoxan (hydrochloride)
Vatinoxan hydrochloride (MK-467 hydrochloride; L-659066 hydrochloride) is a peripheral α2 adrenergic receptor antagonist.
Product Specifications
CAS Number
130466-38-5
Product Name Alternative
MK-467 (hydrochloride) ; L-659066 (hydrochloride)
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Vatinoxan_hydrochloride.html
Purity
99.79
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
[H]Cl.CS(=O)(NCCN([C@]1(CN2)CCN3CCC4=C(OC5=CC=CC=C54)[C@]3([H])C1)C2=O)=O
Molecular Formula
C20H27ClN4O4S
Molecular Weight
454.97
References & Citations
[1]Honkavaara JM, et al. The effects of increasing doses of MK-467, a peripheral alpha (2) -adrenergic receptor antagonist, on the cardiopulmonary effects of intravenous dexmedetomidine in conscious dogs. J Vet Pharmacol Ther. 2011 Aug;34 (4) :332-7.|[2]Honkavaara J, et al. The effect of MK-467, a peripheral α2-adrenoceptor antagonist, on dexmedetomidine-inducedsedation and bradycardia after intravenous administration in conscious cats. Vet Anaesth Analg. 2017 Feb 22. pii: S1467-2987 (16) 31387-3.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α adrenergic receptor
Available Sizes
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