Vatinoxan (hydrochloride)

Vatinoxan hydrochloride (MK-467 hydrochloride; L-659066 hydrochloride) is a peripheral α2 adrenergic receptor antagonist.

Product Specifications

CAS Number

[130466-38-5]

Product Name Alternative

MK-467 (hydrochloride) ; L-659066 (hydrochloride)

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Vatinoxan_hydrochloride.html

Purity

99.79

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

[H]Cl.CS(=O)(NCCN([C@]1(CN2)CCN3CCC4=C(OC5=CC=CC=C54)[C@]3([H])C1)C2=O)=O

Molecular Formula

C20H27ClN4O4S

Molecular Weight

454.97

References & Citations

[1]Honkavaara JM, et al. The effects of increasing doses of MK-467, a peripheral alpha (2) -adrenergic receptor antagonist, on the cardiopulmonary effects of intravenous dexmedetomidine in conscious dogs. J Vet Pharmacol Ther. 2011 Aug;34 (4) :332-7.|[2]Honkavaara J, et al. The effect of MK-467, a peripheral α2-adrenoceptor antagonist, on dexmedetomidine-inducedsedation and bradycardia after intravenous administration in conscious cats. Vet Anaesth Analg. 2017 Feb 22. pii: S1467-2987 (16) 31387-3.