Rabeprazole Sulfide

Rabeprazole Sulfide is an active metabolite of Rabeprazole. Rabeprazole is a proton pump inhibitor that suppresses gastric acid secretion through an interaction with (H+/K+) -ATPase in gastric parietal cells. Rabeprazole markedly inhibits the motility of H. pylori. Rabeprazole has the potential for various peptic diseases treatment[1][2].

Product Specifications

CAS Number

[117977-21-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Bacterial; Proton Pump

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/rabeprazole-sulfide.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=C(OCCCOC)C=CN=C1CSC2=NC3=CC=CC=C3N2

Molecular Formula

C18H21N3O2S

Molecular Weight

343.45

Precautions

H315, H319, H335

References & Citations

[1]Uno T, et al. Determination of rabeprazole and its active metabolite, rabeprazole thioether in human plasma by column-switching high-performance liquid chromatography and its application to pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 25;824 (1-2) :238-43.|[2]Tsutsui N, et al. A novel action of the proton pump inhibitor rabeprazole and its thioether derivative against the motility of Helicobacter pylori. Antimicrob Agents Chemother. 2000 Nov;44 (11) :3069-73.