SAR7334 (hydrochloride)
Product Specifications
UNSPSC Description
SAR7334 hydrochloride is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.
Target Antigen
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/SAR7334-hydrochloride.html
Solubility
DMSO : 100 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Smiles
N[C@@H](C1)CCCN1[C@@H]2CC3=CC=CC=C3[C@H]2OC4=CC=C(C#N)C=C4Cl.Cl.Cl
Molecular Weight
440.79
References & Citations
[1]Ilatovskaya DV, et al. The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling. Sci Rep. 2017 Mar 22;7(1):299.|[2]Chauvet S, et al. Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain. Front Pharmacol. 2016 Dec 12;7:486.|[3]Maier T, et al. Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br J Pharmacol. 2015 Jul;172(14):3650-60.Biochim Biophys Acta. 2017 Jun 16;1863(9):2342-2354.|Cells. 2020 Jan 14;9(1):202.|J Physiol. 2024 Feb 10.|Research Square Preprint. 2024 Mar 28.|Biochim Biophys Acta. 2017 Jul 25;1863(11):2964-2972.|Cell Calcium. 2019 Jan;77:8-19. |Cell Death Dis. 2018 Oct 3;9(10):1015. |Cell Death Dis. 2020 Mar 5;11(3):170.|Eur J Pharmacol. 2022 Sep 7;175254.|Exp Cell Res. 2022 Oct 4;113374.|FASEB J. 2022 Oct;36(10):e22527.|Food Chem Toxicol. 2019 Jul;129:281-290. |Heart Vessels. 2020 Dec;35(12):1755-1765.|J Diabetes Res. 2020 Sep 16;2020:3634974.|J Mol Med (Berl). 2018 Jul;96(7):631-644.|Mol Ther. 2022 Jan 22;S1525-0016(22)00033-8.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15699A/SAR7334-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15699A/SAR7334-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1333207-63-8
Available Sizes
Curated Selection
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