SAR7334 (hydrochloride)
SAR7334 hydrochloride is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.
Product Specifications
CAS Number
[1333207-63-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/SAR7334-hydrochloride.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
N[C@@H](C1)CCCN1[C@@H]2CC3=CC=CC=C3[C@H]2OC4=CC=C(C#N)C=C4Cl.Cl.Cl
Molecular Formula
C21H24Cl3N3O
Molecular Weight
440.79
Precautions
H302, H315, H319, H335
References & Citations
[1]Ilatovskaya DV, et al. The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling. Sci Rep. 2017 Mar 22;7 (1) :299.|[2]Chauvet S, et al. Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain. Front Pharmacol. 2016 Dec 12;7:486.|[3]Maier T, et al. Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br J Pharmacol. 2015 Jul;172 (14) :3650-60.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Biochim Biophys Acta. 2017 Jun 16;1863 (9) :2342-2354.|Cells. 2020 Jan 14;9 (1) :202.|J Physiol. 2024 Feb 10:10.1113/JP286118.|J Physiol. 2025 Aug 28.|Research Square Preprint. 2024 Mar 28.|Biochem Biophys Res Commun. 2025 Nov 1:787:152776.|Biochim Biophys Acta. 2017 Jul 25;1863 (11) :2964-2972.|bioRxiv. 2024 Dec 23:2024.12.23.629519.|Cell Calcium. 2019 Jan:77:8-19.|Cell Death Dis. 2018 Oct 3;9 (10) :1015. |Cell Death Dis. 2020 Mar 5;11 (3) :170.|Eur J Pharmacol. 2022 Oct 15:933:175254.|Exp Cell Res. 2022 Dec 1;421 (1) :113374.|FASEB J. 2022 Oct;36 (10) :e22527.|Food Chem Toxicol. 2019 Jul:129:281-290.|Heart Vessels. 2020 Dec;35 (12) :1755-1765.|J Diabetes Res. 2020 Sep 16;2020:3634974.|J Mol Med (Berl) . 2018 Jul;96 (7) :631-644.|Mol Ther. 2022 Apr 6;30 (4) :1754-1774.|Virulence. 2025 Dec;16 (1) :2490208.
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