(E) -KME-4
(E) -KME-4 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM.
Product Specifications
CAS Number
102271-49-8
Product Name Alternative
PGS-IN-1
UNSPSC
12352005
Target
Lipoxygenase; PGE synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/2_3H_-Furanone,_3-[[3,5-bis_1,1-dimethylethyl_-4-hydroxyphenyl]methylene]dihydro-,__E_-.html
Concentration
10mM
Purity
99.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1OCC/C1=C\C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2
Molecular Formula
C19H26O3
Molecular Weight
302.41
References & Citations
[1]Katsumi I, et al. Studies on styrene derivatives. I. Synthesis and antiinflammatory activities of alpha-benzylidene-gamma-butyrolactone derivatives. Chem Pharm Bull (Tokyo) . 1986 Jan;34 (1) :121-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-LOX
Available Sizes
Frequently Asked Questions
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