LP17 (TFA)

LP17 (LQVTDSGLYRCVIYHPP) TFA is a BBB-penetrable triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. LP17 TFA substantially alleviates ischemia-induced infarction and neuronal injury. LP17 TFA can get access into brain and block TREM-1[1].

Product Specifications

Product Name Alternative

LQVTDSGLYRCVIYHPP (TFA)

UNSPSC

12352209

Target

Others

Type

Peptides

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lqvtdsglyrcviyhpp-tfa.html

Purity

99.85

Solubility

H2O : 3.33 mg/mL (ultrasonic)

Smiles

O=C([C@@H](N)CC(C)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N2[C@H](C(O)=O)CCC2)=O)CCC1)=O)CC3=CNC=N3)=O)CC4=CC=C(O)C=C4)=O)[C@H](CC)C)=O)C(C)C)=O)CS)=O)CCCNC(N)=N)=O)CC5=CC=C(O)C=C5)=O)CC(C)C)=O)=O)CO)=O)CC(O)=O)=O)[C@@H](C)O)=O)C(C)C)=O)CCC(N)=O.OC(C(F)(F)F)=O.[x]

Molecular Formula

C89H137N23O25S.xC2HF3O2

Molecular Weight

1961.24 (free base)

References & Citations

[1]Pengfei Xu, et al. Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke. Cell Death Dis. 2019 Jul 19;10 (8) :555.