T-10418
Product Specifications
UNSPSC Description
T-10418 is an agonist for G2 accumulation protein (G2A) (also known as G protein-coupled receptor GPR132) with an EC50 of 0.82 μM. T-10418 exhibits a sensitizing effect on mouse primary sensory neurons. T-10418 exhibits good pharmacokinetic characteristics, and no obvious toxicity (at 100 μM) in mouse models[1].
Target Antigen
G2A (GPR132)
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/t-10418.html
Smiles
O=C(C1=CC(OCC2=CN=CC=C2)=CC=C1)N[C@H](CC3=CC=CC=C3)C(O)=O
Molecular Weight
376.41
References & Citations
[1]Hernandez-Olmos V, et al., Development of a Potent and Selective G2A (GPR132) Agonist. J Med Chem. 2024 Jun 25.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163763/T-10418-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163763/
Clinical Information
No Development Reported
CAS Number
1608784-68-4
Available Sizes
Curated Selection
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