T-10418
T-10418 is a potent and highly selective G2A/GPR132 agonist. T-10418 has an EC50 of 0.82 μM for human G2A activation. T-10418 has good water solubility, metabolic stability, and pharmacokinetic properties. T-10418 can be used for the research of various diseases such as neuropathic pain, acute myeloid leukemia, and inflammation[1].
Product Specifications
CAS Number
[1608784-68-4]
UNSPSC
12352005
Target
G2A (GPR132)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/t-10418.html
Purity
99.78
Smiles
O=C(C1=CC(OCC2=CN=CC=C2)=CC=C1)N[C@H](CC3=CC=CC=C3)C(O)=O
Molecular Formula
C22H20N2O4
Molecular Weight
376.41
References & Citations
[1]Hernandez-Olmos V, et al., Development of a Potent and Selective G2A (GPR132) Agonist. J Med Chem. 2024 Jun 25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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