PSN 375963
PSN 375963 is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. PSN 375963 shows similar potency to the endogenous agonist oleoylethanolamide (OEA) [1][2].
Product Specifications
CAS Number
[388575-52-8]
UNSPSC
12352005
Target
GPR119
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/psn-375963.html
Purity
99.96
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CCCCC1CCC(C2=NC(C3=CC=NC=C3)=NO2)CC1
Molecular Formula
C17H23N3O
Molecular Weight
285.38
References & Citations
[1]Overton HA, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006;3 (3) :167-175.|[2]Ning Y, et al. Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells. Br J Pharmacol. 2008;155 (7) :1056-1065.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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