PSN 375963

PSN 375963 is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. PSN 375963 shows similar potency to the endogenous agonist oleoylethanolamide (OEA) [1][2].

Product Specifications

CAS Number

[388575-52-8]

UNSPSC

12352005

Target

GPR119

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/psn-375963.html

Purity

99.96

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CCCCC1CCC(C2=NC(C3=CC=NC=C3)=NO2)CC1

Molecular Formula

C17H23N3O

Molecular Weight

285.38

References & Citations

[1]Overton HA, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006;3 (3) :167-175.|[2]Ning Y, et al. Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells. Br J Pharmacol. 2008;155 (7) :1056-1065.