Barlerin

Barlerin (8-O-Acetyl shanzhiside methyl ester) is an iridoid glucoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant in Xi-zang. Barlerin (8-O-Acetyl shanzhiside methyl ester) could inhibt NF-κB.

Product Specifications

CAS Number

[57420-46-9]

Product Name Alternative

8-O-Acetyl shanzhiside methyl ester

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Caspase; NF-κB

Type

Natural Products

Related Pathways

Apoptosis; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/8-O-Acetyl_shanzhiside_methyl_ester.html

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]([C@@H](O)[C@@H]1O)[C@](O[C@@H]1CO)([H])O[C@H]2[C@@]([C@@]3(C)OC(C)=O)([H])[C@@]([C@H](O)C3)([H])C(C(OC)=O)=CO2

Molecular Formula

C19H28O12

Molecular Weight

448.42

Precautions

H302, H315, H319

References & Citations

[1]Zhang L, et al. 8-O-acetyl shanzhiside methylester attenuates cerebral ischaemia/reperfusion injury through an anti-inflammatory mechanism in diabetic rats. Basic Clin Pharmacol Toxicol. 2014 Dec;115 (6) :481-7.|[2]Kang ZC, et al. Cardioprotection with 8-O-acetyl shanzhiside methylester on experimental myocardial ischemia injury. Eur J Pharm Sci. 2012 Aug 30;47 (1) :124-30.|[3]Jiang WL, et al. Effect of 8-O-acetyl shanzhiside methylester increases angiogenesis and improves functional recovery after stroke. Basic Clin Pharmacol Toxicol. 2011 Jan;108 (1) :21-7.|[4]Fan PC, et al. A new anti-fibrinolytic hemostatic compound 8-O-acetyl shanzhiside methylester extracted from Lamiophlomis rotata. J Ethnopharmacol. 2016 Jul 1;187:232-8.