JNJ-7777120
JNJ-7777120 is a potent and selective histamine H4 receptor antagonist (Ki=4.5 nM) . JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis model. JNJ-7777120 has a good potential to study antipruritic and anti-inflammatory[1][2].
Product Specifications
CAS Number
459168-41-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/JNJ-7777120.html
Concentration
10mM
Purity
99.96
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(C(N1)=CC2=C1C=CC(Cl)=C2)N3CCN(C)CC3
Molecular Formula
C14H16ClN3O
Molecular Weight
277.75
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H4 Receptor
Available Sizes
Frequently Asked Questions
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