JNJ-7777120

JNJ-7777120 is a potent and selective histamine H4 receptor antagonist (Ki=4.5 nM) . JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis model. JNJ-7777120 has a good potential to study antipruritic and anti-inflammatory[1][2].

Product Specifications

CAS Number

[459168-41-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/JNJ-7777120.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(C(N1)=CC2=C1C=CC(Cl)=C2)N3CCN(C)CC3

Molecular Formula

C14H16ClN3O

Molecular Weight

277.75

Precautions

H302, H315, H319, H335

References & Citations

[1]Thurmond RL, et al. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther. 2004 Apr;309 (1) :404-13. |[2]Ohsawa Y, et al. The antagonism of histamine H1 and H4 receptors ameliorates chronic allergic dermatitis via anti-pruritic and anti-inflammatory effects in NC/Nga mice. Allergy. 2012 Aug;67 (8) :1014-22.