FR122047

FR122047 (hydrochloride) is a selective and oral active inhibitor of COX-1 with an IC50 of 28 nM. FR122047 hydrochloride has antiplatelet, analgesic and anti-inflammatory effects in vivo[1][2][3].

Product Specifications

CAS Number

[130717-51-0]

UNSPSC

12352005

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/fr122047.html

Purity

99.55

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=NC(C2=CC=C(OC)C=C2)=C(C3=CC=C(OC)C=C3)S1)N4CCN(C)CC4.[H]Cl

Molecular Formula

C23H26ClN3O3S

Molecular Weight

459.99

References & Citations

[1]Dohi M, et al. The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor. Eur J Pharmacol. 1993 Oct 19;243 (2) :179-84. |[2]Ochi T, Motoyama Y, Goto T. The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models. Eur J Pharmacol. 2000 Mar 10;391 (1-2) :49-54.|[3]Ochi T, Goto T. Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis. Br J Pharmacol. 2002 Feb;135 (3) :782-8.