HBDDE
HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis[1][2].
Product Specifications
CAS Number
154675-18-0
UNSPSC
12352005
Target
Apoptosis; PKC
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; TGF-beta/Smad
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hbdde.html
Purity
98.03
Solubility
DMSO : 5 mg/mL (ultrasonic; warming)
Smiles
OC1=CC(COC)=C(C2=C(C(O)=C(C=C2COC)O)O)C(O)=C1O
Molecular Formula
C16H18O8
Molecular Weight
338.31
References & Citations
[1]A Mathur, et al. 2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether (HBDDE) -induced neuronal apoptosis independent of classical protein kinase C alpha or gamma inhibition. Biochem Pharmacol. 2000 Sep 15;60 (6) :809-15.|[2]Y Kashiwada, et al. New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C. J Med Chem. 1994 Jan 7;37 (1) :195-200.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKCα; PKCγ
Available Sizes
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