HBDDE

HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis[1][2].

Product Specifications

CAS Number

[154675-18-0]

UNSPSC

12352005

Target

Apoptosis; PKC

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics; TGF-beta/Smad

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hbdde.html

Purity

98.03

Solubility

DMSO : 5 mg/mL (ultrasonic; warming)

Smiles

OC1=CC(COC)=C(C2=C(C(O)=C(C=C2COC)O)O)C(O)=C1O

Molecular Formula

C16H18O8

Molecular Weight

338.31

References & Citations

[1]A Mathur, et al. 2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether (HBDDE) -induced neuronal apoptosis independent of classical protein kinase C alpha or gamma inhibition. Biochem Pharmacol. 2000 Sep 15;60 (6) :809-15.|[2]Y Kashiwada, et al. New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C. J Med Chem. 1994 Jan 7;37 (1) :195-200.