Ro 90-7501

Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM) . Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response[2]. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner[3]. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells[4].

Product Specifications

CAS Number

[293762-45-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Amyloid-β; Apoptosis; ATM/ATR; Phosphatase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Neuronal Signaling; PI3K/Akt/mTOR

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ro-90-7501.html

Purity

99.10

Solubility

DMSO : 41.67 mg/mL (ultrasonic)

Smiles

NC1=CC=C2C(N=C(C3=CC=C4C(N=C(C5=CC=C(N)C=C5)N4)=C3)N2)=C1

Molecular Formula

C20H16N6

Molecular Weight

340.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Tamari K, et al. Ro 90-7501 Is a Novel Radiosensitizer for Cervical Cancer Cells that Inhibits ATM Phosphorylation. Anticancer Res. 2019 Sep;39 (9) :4805-4810.|[2]Bohrmann B, et al. Self-assembly of beta-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates. J Struct Biol. 2000 Jun;130 (2-3) :232-46.|[3]Hong TJ, et al. Ro 90-7501 inhibits PP5 through a novel, TPR-dependent mechanism. Biochem Biophys Res Commun. 2017 Jan 8;482 (2) :215-220.|[4]Guo F, et al. RO 90-7501 enhances TLR3 and RLR agonist induced antiviral response. PLoS One. 2012;7 (10) :e42583.