AZ 628

AZ 628 is a pan-Raf kinase inhibitor with IC50s of 105, 34 and 29 nM for B-Raf, B-RafV600E, and c-Raf-1, respectively.

Product Specifications

CAS Number

[878739-06-1]

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

Apoptosis; Raf

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AZ-628.html

Purity

99.44

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C1N(C)C=NC2=C1C=C(C=C2)NC3=C(C)C=CC(NC(C4=CC(C(C#N)(C)C)=CC=C4)=O)=C3

Molecular Formula

C27H25N5O2

Molecular Weight

451.52

Precautions

H301, H315, H319, H335

References & Citations

[1]Khazak V, et al. Selective Raf inhibition in cancer therapy. Expert Opin Ther Targets. 2007 Dec;11 (12) :1587-609.|[2]Lau KS, et al. BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner. PLoS One. 2012;7 (7) :e41343.