ITGAE (heavy chain, Cleaved-Ala179) rabbit pAb

Integrin subunit alpha E (ITGAE) Homo sapiens Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008],

Product Specifications

Background

UniProt

P38570

Swiss Prot

P38570

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from human ITGAE (heavy chain, Cleaved-Ala179)

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC

Concentration

1 mg/ml

Dilution

WB 1:500-2000; IHC-p 1:50-300

Molecular Weight

110 128kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

110 128kD

Fragment

IgG

Subcellular Location

Membrane; Single-pass type I membrane protein.

Other Product Names

Integrin alpha-E (HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; CD antigen CD103) [Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain]