Neticonazole

Neticonazole is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole has anti-infection and anti-cancer effects[1][2][3].

Product Specifications

CAS Number

[130726-68-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/neticonazole.html

Purity

99.88

Solubility

1M HCl : 100 mg/mL (ultrasonic; adjust pH to 1 with HCl) |DMSO : 250 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCCCCOC1=CC=CC=C1/C(N2C=CN=C2)=C\SC

Molecular Formula

C17H22N2OS

Molecular Weight

302.43

Precautions

H302, H315, H319

References & Citations

[1]Tsuboi R, et al. Hyperkeratotic chronic tinea pedis treated with neticonazole cream. Neticonazole Study Group. Int J Dermatol. 1996 May;35 (5) :371-3.|[2]Datta A, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8 (1) :8161.|[3]Gu L, et al. The exosome secretion inhibitor neticonazole suppresses intestinal dysbacteriosis-induced tumorigenesis of colorectal cancer. Invest New Drugs. 2020 Apr;38 (2) :221-228.