FAUC 365

FAUC 365 is a highly dopamine D3 receptor-selective antagonist with Ki values of 0.5 nM, 340, 2600, and 3600 nM at D3, D4.4, D2short, and D2Long receptors, respectively. FAUC 365 can be used for the research of schizophrenia, and Parkinson's disease[1][2].

Product Specifications

CAS Number

[474432-66-1]

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/fauc-365.html

Concentration

10mM

Purity

98.75

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

ClC1=C(C(N2CCN(CC2)CCCCNC(C3=CC4=C(S3)C=CC=C4)=O)=CC=C1)Cl

Molecular Formula

C23H25Cl2N3OS

Molecular Weight

462.44

References & Citations

[1]Philip Seeman, et al. Dopamine D2 and D3 receptors in human putamen, caudate nucleus, and globus pallidus. Synapse. 2006 Sep 1;60 (3) :205-11.|[2]Carsten Hocke, et al. Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype. Bioorg Med Chem Lett. 2004 Aug 2;14 (15) :3963-6.