IHMT-RAF-128
IHMT-RAF-128, a highly potent pan-RAF inhibitor. IHMT-RAF-128 shows potent antitumor efficacy in xenograft mouse tumor models without causing any apparent toxicities[1][2].
Product Specifications
CAS Number
2479289-15-9
UNSPSC
12352005
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ihmt-raf-128.html
Smiles
FC(F)(F)C1=CC(C(NC2=CC(N3N=CC(C4=CC(N5CCOCC5)=CN=C4)=C3)=C(C)C=C2)=O)=CC=C1
Molecular Formula
C27H24F3N5O2
Molecular Weight
507.51
References & Citations
[1]Olaoba OT, et al. Driver Mutations in Pancreatic Cancer and Opportunities for Targeted Therapy. Cancers (Basel) . 2024 May 9;16 (10) :1808.|[2]Wang A, et al. Discovery of a highly potent pan-RAF inhibitor IHMT-RAF-128 for cancer treatment. Eur J Pharmacol. 2023 Aug 5;952:175752.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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