8-Hydroxyefavirenz

8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of (HY-10572) . 8-Hydroxyefavirenz induces apoptosis via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. 8-Hydroxyefavirenz can be used in research of cancer[1]. 8-Hydroxyefavirenz is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[205754-33-2]

Product Name Alternative

8-OH-EFV

UNSPSC

12352005

Hazard Statement

H302-H360-H410

Target

Apoptosis; JNK

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/8-hydroxyefavirenz.html

Purity

98.0

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1NC2=C(O)C=C(Cl)C=C2[C@](C(F)(F)F)(C#CC3CC3)O1

Molecular Formula

C14H9ClF3NO3

Molecular Weight

331.67

Precautions

P264-P270-P273-P280-P330-P391-P405-P501

References & Citations

[1]Bumpus NN. Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. Toxicol Appl Pharmacol. 2011 Dec 1;257 (2) :227-34.