P, p'-DDE (Standard)
P, p'-DDE (Standard) is the analytical standard of p, p'-DDE. This product is intended for research and analytical applications. p, p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p, p'-DDE is a orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. p, p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p, p'-DDE may be a risk factor for type 2 diabetes in women[1].
Product Specifications
CAS Number
[72-55-9]
Product Name Alternative
4,4'-DDE (Standard) ; p, p'-Dichlorodiphenyldichloroethylene (Standard)
UNSPSC
12352005
Target
Androgen Receptor; Drug Metabolite; Reference Standards
Type
Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/p-p-dde-standard.html
Smiles
Cl/C(Cl)=C(C1=CC=C(Cl)C=C1)/C2=CC=C(Cl)C=C2
Molecular Formula
C14H8Cl4
Molecular Weight
318.03
References & Citations
[1]Kelce WR, et al. Persistent DDT metabolite p, p'-DDE is a potent androgen receptor antagonist. Nature. 1995;375 (6532) :581-585.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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