IL17A Receptor Recombinant Rabbit Monoclonal Antibody [JE35-89]
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
IL17RA, IL17R
Swiss Prot
Q96F46 Human
Cellular Locus
Cell membrane, Secreted.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within Human IL17A Receptor aa 801-850 / 866.
Isotype
IgG
Clone
JE35-89
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell
Positive Control
THP-1 cell lysate, HeLa cell lysate, K-562 cell lysate, Jurkat cell lysate, Raji cell lysate, HL-60 cell lysate, HeLa.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IF-Cell: 1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 96 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
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