Osoresnontrine
Osoresnontrine (BI-409306) is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 μM), PDE1C (IC50, 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM) ; Osoresnontrine can be used in the research of memory enhancement in CNS disorders.
Product Specifications
CAS Number
[1189767-28-9]
Product Name Alternative
BI-409306
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/BI-409306.html
Concentration
10mM
Purity
99.88
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(N(C3CCOCC3)N=C2)NC(CC4=CC=CC=N4)=N1
Molecular Formula
C16H17N5O2
Molecular Weight
311.34
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PDE1; PDE9
Available Sizes
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