Osoresnontrine

Osoresnontrine (BI-409306) is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 μM), PDE1C (IC50, 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM) ; Osoresnontrine can be used in the research of memory enhancement in CNS disorders.

Product Specifications

CAS Number

[1189767-28-9]

Product Name Alternative

BI-409306

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/BI-409306.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=C(N(C3CCOCC3)N=C2)NC(CC4=CC=CC=N4)=N1

Molecular Formula

C16H17N5O2

Molecular Weight

311.34

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Cornelia Dorner-Ciossek, et al. BI 409306, a novel phosphodiesterase 9A inhibitor, part I: potency, selectivity and in-vitro functional characterization on synaptic plasticity. International Congress on Schizophrenia Research.