SBI-477
SBI-477 is a chemical probe that stimulates insulin signaling by deactivating the transcription factor MondoA. SBI-477 can lead to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4) . SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes[1].
Product Specifications
CAS Number
781628-99-7
UNSPSC
12352005
Target
Arrestin; Fluorescent Dye; Insulin Receptor; LXR
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Others; Protein Tyrosine Kinase/RTK; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sbi-477.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 65 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC(C2=CC=C(OC)C=C2)=CS1)C3=CC=C(OCC(N4CCOCC4)=O)C(OC)=C3
Molecular Formula
C24H25N3O6S
Molecular Weight
483.54
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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