4-Chlorocinnamic acid

4-Chlorocinnamic acid is a derivative of Cinnamic acid (HY-N0610A) . 4-Chlorocinnamic acid inhibits the monophenolase and diphenolase activities of mushroom tyrosinase with IC50 values of 0.477 mM and 0.229 mM, respectively. 4-Chlorocinnamic acid inhibits the mycelial growth of Colletotrichum gloeosporioides. 4-Chlorocinnamic acid exhibits anticonvulsant activity against acute epilepsy induced by pentylenetetrazol[1][2][3][4].

Product Specifications

CAS Number

[1615-02-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Drug Derivative; Fungal; Tyrosinase

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/4-chlorocinnamic-acid.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)/C=C/C1=CC=C(Cl)C=C1

Molecular Formula

C9H7ClO2

Molecular Weight

182.61

Precautions

H302, H315, H319, H335

References & Citations

[1]Cui Y, et al. Inhibition kinetics and molecular simulation of p-substituted cinnamic acid derivatives on tyrosinase. Int J Biol Macromol. 2017 Feb;95:1289-1297.|[2]Silva RHN, et al. Antimicrobial Activity of 4-Chlorocinnamic Acid Derivatives. Biomed Res Int. 2019 Apr 23;2019:3941242.|[3]Kátia Aparecida de Siqueira, et al. Isolation of 4-chlorocinnamic acid from Streptomyces griseocarneus R132, and its inhibition activity against sweet pepper postharvest anthracnose. Biocontrol Science and Technology. Volume 32, 2022-Issue 6|[4]Cuan Y, et al. Anticonvulsant Activity of Halogen-Substituted Cinnamic Acid Derivatives and Their Effects on Glycosylation of PTZ-Induced Chronic Epilepsy in Mice. Molecules. 2017 Dec 29;23 (1) :76.