SDF-1, Canine

SDF-1 (stromal cell-derived factor-1) is a homeostatic chemokine that binds CXCR4 and CXCR7 receptors and physiologically functions in hematopoiesis, leucocyte trafficking, cardiogenesis, and neurogenesis. SDF-1 is constitutively expressed in several organs including lung, liver, skeletal muscle, brain, kidney, heart, skin, and bone marrow. SDF-1 has an essential role in neural and vascular development, hematopoiesis, cancer and in immunity[1][2][3]. SDF-1 Protein, Canine is produced in E. coli, and consists of 72 amino acids (K22-M93) .

Product Specifications

Product Name Alternative

SDF-1 Protein, Canine, Canine, E. coli

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/sdf-1-protein-canine.html

Purity

95.0

Molecular Formula

449622 (Gene_ID) Q3LSL4 (K22-M93) (Accession)

Molecular Weight

Approximately 14 kDa, based on SDS-PAGE under reducing conditions.

References & Citations

[1]Beverly A Teicher, et al. CXCL12 (SDF-1) /CXCR4 pathway in cancer. Clin Cancer Res. 2010 Jun 1;16 (11) :2927-31.|[2]Luigi Portella, et al. CXCL12 Signaling in the Tumor Microenvironment. Adv Exp Med Biol. 2021;1302:51-70.|[3]Gordana Timotijević, et al. CXCL12: role in neuroinflammation. Int J Biochem Cell Biol. 2012 Jun;44 (6) :838-41.