SARS-CoV-IN-3

SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC50 of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 11.7 and 20.4 nM; and IC90s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1-induced cytopathic effect with an EC50 of 10 μM in MT-4 cells[1].

Product Specifications

CAS Number

[888958-27-8]

UNSPSC

12352005

Target

HIV; Parasite; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sars-cov-in-3.html

Purity

99.36

Solubility

DMSO : 7.81 mg/mL (ultrasonic)

Smiles

CCN(CCO)CC12=C3[Fe+2]145678(C9=C43)([C-]%10C5=C6C7=C8%10)[C-]29CNC%11=CC=NC%12=C%11C=CC(Cl)=C%12

Molecular Formula

C25H20ClFeN3O

Molecular Weight

469.74

References & Citations

[1]Biot C, et al. Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities. J Med Chem. 2006 May 4;49 (9) :2845-9.