BVT948
BVT948 is a protein tyrosine phosphatase (PTP) inhibitor which can also inhibit several cytochrome P450 (P450) isoforms and lysine methyltransferase SETD8 (KMT5A) .
Product Specifications
CAS Number
[39674-97-0]
UNSPSC
12352005
Hazard Statement
H317
Target
Cytochrome P450; Histone Methyltransferase; Phosphatase
Type
Reference compound
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BVT948.html
Purity
99.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(O)=C2C(C3=C1C=CC=C3)=NC(C2(C)C)=O
Molecular Formula
C14H11NO3
Molecular Weight
241.24
Precautions
H317
References & Citations
[1]Liljebris C, et al. Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5 (3H) -dione. J Pharmacol Exp Ther. 2004 May;309 (2) :711-9.|[2]Blum G, et al. Small-molecule inhibitors of SETD8 with cellular activity. ACS Chem Biol. 2014 Nov 21;9 (11) :2471-8.|[3]Hwang BM, et al. Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9. BMB Rep. 2013 Nov;46 (11) :533-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SETD8/KMT5A
Available Sizes
Curated Selection
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