18α-Glycyrrhetinic acid
Product Specifications
UNSPSC Description
18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2].
Target Antigen
Apoptosis; NF-κB; Proteasome
Type
Natural Products
Related Pathways
Apoptosis;Metabolic Enzyme/Protease;NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/18_alpha_-Glycyrrhetinic_acid.html
Purity
99.52
Solubility
DMSO : 11.36 mg/mL (ultrasonic)
Smiles
CC1(C)[C@@H](O)CC[C@@]2(C)[C@@]1([H])CC[C@]([C@@](CC[C@]3(C)[C@]4([H])C[C@@](C)(C(O)=O)CC3)(C)C4=C5)(C)[C@]2([H])C5=O
Molecular Weight
470.68
References & Citations
[1]Zong L et al. 18α-glycyrrhetinic acid extracted from Glycyrrhiza radix inhibits proliferation and promotes apoptosis of the hepatic stellate cell line. J Dig Dis. 2013 Jun;14(6):328-36.|[2]Papaevgeniou N, et al. 18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures. Antioxid Redox Signal. 2016 Dec 1;25(16):855-869.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0375/18α-Glycyrrhetinic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0375/18α-Glycyrrhetinic-acid-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
1449-05-4
Available Sizes
Curated Selection
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