18α-Glycyrrhetinic acid

18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2].

Product Specifications

CAS Number

[1449-05-4]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; NF-κB; Proteasome

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/18_alpha_-Glycyrrhetinic_acid.html

Concentration

10mM

Purity

99.87

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1(C)[C@@H](O)CC[C@@]2(C)[C@@]1([H])CC[C@]([C@@](CC[C@]3(C)[C@]4([H])C[C@@](C)(C(O)=O)CC3)(C)C4=C5)(C)[C@]2([H])C5=O

Molecular Formula

C30H46O4

Molecular Weight

470.68

Precautions

H302, H315, H319, H335

References & Citations

[1]Zong L et al. 18α-glycyrrhetinic acid extracted from Glycyrrhiza radix inhibits proliferation and promotes apoptosis of the hepatic stellate cell line. J Dig Dis. 2013 Jun;14 (6) :328-36.|[2]Papaevgeniou N, et al. 18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures. Antioxid Redox Signal. 2016 Dec 1;25 (16) :855-869.