Dehydrocholic acid

Dehydrocholic acid (Dehydrocholate) is an orally active hydrocholeretic agent. Dehydrocholic acid modulates Autophagy, reduces serum amylase and lipase levels. Dehydrocholic acid has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholic acid can be used in the study of acute biliary pancreatitis and obstructive jaundice[1][2][3][4][5].

Product Specifications

CAS Number

[81-23-2]

Product Name Alternative

Dehydrocholate

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Amylases; Autophagy; Lipase

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Dehydrocholic-acid.html

Purity

99.92

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

C[C@H](CCC(O)=O)[C@H]([C@]12C)CC[C@@]1([H])[C@]3([H])C(C[C@]4([H])CC(CC[C@]4(C)[C@@]3([H])CC2=O)=O)=O

Molecular Formula

C24H34O5

Molecular Weight

402.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang X, et al. Dehydrocholic Acid Ameliorates Sodium Taurocholate-Induced Acute Biliary Pancreatitis in Mice. Biol Pharm Bull. 2020;43 (6) :985-993.|[2]Yousef IM, et al. Influence of dehydrocholic acid on the secretion of bile acids and biliary lipids in rats. Digestion. 1990;45 (1) :40-51.|[3]Ratan J, et al. A controlled trial of choleretic and hepatoprotective actions of Livzon and dehydrocholic acid in a model of obstructive jaundice in albino rats. Tohoku J Exp Med. 1997 Jan;181 (1) :161-6.|[4]UCHIDA K, et al. EFFECTS OF SODIUM URSODEOXYCHOLATE, HYODEOXY-CHOLATE AND DEHYDROCHOLATE ON CHOLESTEROL AND BILE ACID METABOLISM IN RATS. Journal of Pharmacobio-Dynamics, 1983, 6 (5) : 346-357.|[5]Magos L, et al. The effect of phenobarbital and sodium dehydrocholate on the biliary excretion of methylmercury in the rat. Toxicology and Applied Pharmacology, 1974, 30 (1) : 1-6.